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KMID : 1103720170760030179
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Journal of the Korean Society of Radiology
2017 Volume.76 No. 3 p.179 ~ p.186
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Analysis of Factors Affecting Local Tumor Progression of Colorectal Cancer Liver Metastasis after Radiofrequency Ablation
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Jeon Seong-Hee
Cho Yun-Ku
Choi Seung-A
Kim Mi-Young
Lee Ho-Suk
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Abstract
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Purpose: The purpose of this study was to evaluate the independent predictive factors for local tumor progression (LTP) of colorectal liver metastasis (CRLM) after radiofrequency ablation (RFA).
Materials and Methods: Patients with CRLM were included in the analysis if nodules were up to five in number, each nodule was ≤ 5 cm, and RFA was performed in our center from January 2006 to December 2015. Univariate and multivariate analyses to identify the predictors of LTP were performed by using a Cox proportional hazard model.
Results: Overall, 58 tumors from 38 patients were included in this study. LTP occurred in 14 tumors from 9 patients. The overall 1- and 3-year LTP rates were 23.5% and 29.4%, respectively. Multivariate analysis showed that tumor size > 2 cm and insufficient ablative margin were two independently significant adverse prognostic factors for LTP (p = 0.045 and 0.022, respectively). The 3-year LTP rates for 33 and 25 tumors with and without sufficient ablative margin were 4.5% and 61.2%, respectively. The difference was statistically significant (p < 0.001). The difference in the 3-year LTP rates according to the tumor size was not statistically significant (p = 0.791).
Conclusion: Insufficient ablative margin seems to be the most potent predictor of LTP after RFA of CRLM.
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KEYWORD
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Local Neoplasm Recurrence, Neoplasm Metastasis, Radiofrequency Thermal Ablation, Colorectal Neoplasm, Laparoscopy
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